Dual Incretin Pathway with Mitochondrial Metabolic Support
Mechanistic Synergy for Research:
- Tirzepatide activates both GLP-1 and GIP receptors, promoting superior insulin sensitivity, glucagon suppression, and appetite regulation compared to GLP-1 alone.
- NAD⁺ enhances mitochondrial biogenesis, oxidative phosphorylation, and supports sirtuin-driven glucose regulation.
Combined Benefits:
- Tirzepatide improves beta-cell responsiveness and glucose disposal; NAD⁺ amplifies mitochondrial fuel utilization.
- SIRT1 and AMPK activation by NAD⁺ complements incretin signaling for full-spectrum metabolic restoration.
Use Cases:
Dual incretin receptor studies, energy metabolism models, advanced obesity or type 2 diabetes frameworks.
